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-synuclein, that's a principal part of Lewy bodies, in PARK one in 1997 and parkin in PARK two in 1998, which happens to be an E3 ubiquitin ligase and triggers endoplasmic reticulum (ER) tension, propose that dysfunction in the intracellular proteinase programs, such as ubiquitin-proteasome process or lysosomal procedure, which gets rid of pointles

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